L2C guinea pig leukemia: Immunoprotection and immunotherapy

L2C Guinea pig lymphatic leukemia: a "B" cell leukemia.

[Immunotherapeutic studies on EN-L2C guinea pig leukemia].

Effect of various immunomodulators in combination with chemotherapeutic agents were studied using EN-L2C cell line, an acute lymphoblastic leukemia (ALL) of inbred strain-2 guinea pig. Results obtained were followings. 1) Typical leukemic cells appeared in peripheral blood 12 days after the inoculation of 10, cells and the hosts died within 5 days. When EN-L2C cells were inoculated together wit...

Karyotype of Hairless Guinea pig

Chromosomal patterns of experimental animals are useful tools for cytogenetics research and animal breeding. Chromosome investigations of the hairless guinea pig are rare, therefore, karyotype of hairless guinea pigs (twelve male and female) was studied using metaphase spreads of bone marrows and G banding techniques. The chromosomes diploid number was 2n= 64 and polymorphism of three type chro...

Corticosteroid Production Rates in Strain 2 Guinea Pigs following L2C/NB Leukemia Transplantation1

Production rates of cortisol, 2a-hydroxycortisol, and 6/3hydroxycortisol were determined (by isotope dilution technics) in individual adult Strain 2 guinea pigs following transplantation of the guinea pig lymphoblastic leukemia I^C/NB. There was a statistically significant (P < 0.01, 0.02, and 0.01) 2.0-, 1.4-, and 1.9-fold higher production of cortisol, 2a-hydroxycortisol, and 6/3-hydroxycorti...

Corticosteroid production rates in strain 2 guinea pigs following L2C-NB leukemia transplantation.

Production rates of cortisol, 2a-hydroxycortisol, and 6/3hydroxycortisol were determined (by isotope dilution technics) in individual adult Strain 2 guinea pigs following transplantation of the guinea pig lymphoblastic leukemia I^C/NB. There was a statistically significant (P < 0.01, 0.02, and 0.01) 2.0-, 1.4-, and 1.9-fold higher production of cortisol, 2a-hydroxycortisol, and 6/3-hydroxycorti...