l-(−)-Desmethylselegiline, a Metabolite of Selegiline [l-(−)-Deprenyl], Protects Mesencephalic Dopamine Neurons from Excitotoxicity In Vitro
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چکیده
منابع مشابه
Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion.
Oxidative stress is thought to play an important role in the pathogenesis of Parkinson's disease (PD). Glutathione (GSH), a major cellular antioxidant, is decreased in the substantia nigra pars compacta of PD patients. The aim of the present study was to investigate whether deprenyl and its desmethyl metabolite, putative neuroprotective agents in the treatment of PD, could protect cultured rat ...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2002
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.1997.68010434.x