L -Arginine deprivation impairs Leishmania major -specific T-cell responses

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l-Arginine deprivation impairs Leishmania major-specific T-cell responses

The amino acid L-arginine plays a crucial role in the regulation of immune responses. We have recently shown that uncontrolled replication of Leishmania parasites at the site of pathology correlates with high levels of arginase activity in nonhealing leishmaniasis and that this elevated arginase activity causes local depletion of L-arginine. To further our understanding of the impact of L-argin...

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ژورنال

عنوان ژورنال: European Journal of Immunology

سال: 2009

ISSN: 0014-2980

DOI: 10.1002/eji.200839041