منابع مشابه
Kynurenine pathway metabolites and suicidality
Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood. Suicidal patients have been shown to display elevated levels of inflammation both in the central nervous system and the peripheral blood. A growing body of evidence suggests that inflammation is associated with a dysregu...
متن کاملKynurenine Metabolites and Migraine: Experimental Studies and Therapeutic Perspectives
Migraine is one of the commonest neurological disorders. Despite intensive research, its exact pathomechanism is still not fully understood and effective therapy is not always available. One of the key molecules involved in migraine is glutamate, whose receptors are found on the first-, second- and third-order trigeminal neurones and are also present in the migraine generators, including the do...
متن کاملKynurenine Pathway Metabolites in Humans: Disease and Healthy States
Tryptophan is an essential amino acid that can be metabolised through different pathways, a major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2,3-dioxygenase, is strongly stimulated by inflammatory molecules, particularly interferon gamma. Thus, the kynurenine pathway is often systematically up-regulated when the immune response is activated. The biological ...
متن کاملPeripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure.
We investigated L-kynurenine distribution and metabolism in rats with experimental chronic renal failure of various severity, induced by unilateral nephrectomy and partial removal of contralateral kidney cortex. In animals with renal insufficiency the plasma concentration and the content of L-tryptophan in homogenates of kidney, liver, lung, intestine and spleen were significantly decreased. Th...
متن کاملMaternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia.
OBJECTIVE To estimate the association of maternal plasma concentrations of tryptophan and six kynurenine pathway metabolites with the risk of preeclampsia. METHODS The study was based on a subsample of 2,936 pregnant women who delivered singleton neonates in the Norwegian Mother and Child Cohort Study in 2002-2003. Maternal blood plasma was obtained at approximately gestational week 18 and wa...
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ژورنال
عنوان ژورنال: The Journal of Headache and Pain
سال: 2015
ISSN: 1129-2369,1129-2377
DOI: 10.1186/1129-2377-16-s1-a1