Kynurenine Metabolism in Hyperthyroidism

Kynurenine metabolism in hyperthyroidism. A biochemical basis for the low NAD(P) level in hyperthyroid rat liver.

Subcutaneous administration of L-thyroxine (75 pg/lOO g of body weight per day) to rats for 10 to 14 days caused a decrease in the activity of kynurenine 3-hydroxylase to about 50% of the control value. Enzymic properties of kynurenine 3-hydroxylase of mitochondrial outer membrane preparations isolated from normal and L-thyroxine-treated rats were almost identical, suggesting that L-thyroxine a...

Kynurenine pathway metabolism and neuroinflammatory disease

Immune-mediated activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP) is a consistent finding in all inflammatory disorders. Several studies by our group and others have examined the neurotoxic potential of neuroreactive TRYP metabolites, including quinolinic acid (QUIN) in neuroinflammatory neurological disorders, including Alzheimer's disease (AD), multiple sclerosis, amy...

Magnesium metabolism in hyperthyroidism and hypothyroidism.

Kynurenine hydroxylase: a potential rate-limiting enzyme in tryptophan metabolism.

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Tryptophan-Kynurenine Metabolism and Insulin Resistance in Hepatitis C Patients

Chronic hepatitis C virus (HCV) infection is associated with 50% incidence of insulin resistance (IR) that is fourfold higher than that in non-HCV population. IR impairs the outcome of antiviral treatment. The molecular mechanisms of IR in HCV are not entirely clear. Experimental and clinical data suggested that hepatitis C virus per se is diabetogenic. However, presence of HCV alone does not a...