Kynurenine Formamidase and Tetrahydrofolic Acid.
نویسندگان
چکیده
منابع مشابه
Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster.
KFase (kynurenine formamidase), also known as arylformamidase and formylkynurenine formamidase, efficiently catalyses the hydrolysis of NFK (N-formyl-L-kynurenine) to kynurenine. KFase is the second enzyme in the kynurenine pathway of tryptophan metabolism. A number of intermediates formed in the kynurenine pathway are biologically active and implicated in an assortment of medical conditions, i...
متن کاملFormimino transfer from formamidinoglutaric acid to tetrahydrofolic acid.
The enzymatic formation of PO-CHOeFA’ from FA with FAG as the specific formyl donor and with a soluble liver extract as the source of enzymes has been described in the preceding paper (1). The specific l-carbon acceptor appeared to be FAHd which functioned catalytically. When FAG and substrate amounts of FAHd were incubated with enzyme and the reaction mixture acidified, ACF could be detected a...
متن کاملThe dissociation constants of tetrahydrofolic acid.
Six dissociable groups exist in tetrahydrofolic acid in the range Ho -3.0 to pH 14. The assignments in tetrahydrofolic acid by titrimetric and spectrophotometric comparisons with model compounds, +uninobenzoylglutamic acid and 2-amino-6,7-dimethyl-5,6,7,8-tetrahydro-4-pteridinone, are as follows: acidic ionization of amide, pK’ 10.5; Ns, pK’ 4.82; y-carboxyl, pK’ 4.8; cr-carboxyl, pK’ 3.5; N1, ...
متن کاملEnzymatic reduction of folic acid and dihydrofolic acid to tetrahydrofolic acid.
Earlier reports on the inactivation of FA’ in the presence of liver extracts indicated the supplements required (1, 2) and described the enzymatic conversion of FA to a labile compound possessing the properties of FAH4 (3). The reduction of FA by TPNH has been noted by Miller and Waelsch (4). Recently, the enzymatic reduction of FA to FAHz by a bacterial extract was described by Wright and Ande...
متن کامل5-Methyl-5,6,7,8-tetrahydrofolic acid. Conformation of the tetrahydropyrazine ring.
It is suggested from analysis of proton spin-spin coupling constants that the tetrahydropyrazine ring of 5methyltetrahydrofolate in solution is in a half-chair conformation, with the methyl group at N-5 and the methylene group C-9 truns, and with C-6-H in an equatorial position. The chemical shifts and spin-spin coupling constants for the carbon-bound hydrogens of (+)-L-, (-)-L, (+)-L-~-‘H, 7-‘...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1968
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.22-3321