KVchannel trafficking and control of vascular tone

Sphingosine 1-phosphate and control of vascular tone.

Sphingosine-1-phosphate (S1P) is a platelet-derived lipid mediator that activates the endothelial isoform of nitric oxide synthase (eNOS) in endothelial cells. However, the role of S1P in endothelium-dependent vasodilation and the signaling pathways elicited by S1P in intact vessels are largely unknown. We found that S1P induces dose-dependent transient relaxation of isolated pressurized mesent...

Y1- and 1-receptor control of basal hindlimb vascular tone

Jackson, Dwayne N., Earl G. Noble, and J. Kevin Shoemaker. Y1and 1-receptor control of basal hindlimb vascular tone. Am J Physiol Regul Integr Comp Physiol 287: R228–R233, 2004. First published March 25, 2004; 10.1152/ajpregu.00723.2003.—The role of endogenous Y1-receptor activation on skeletal muscle vasculature under baseline conditions is currently debated and no in vivo studies have been pe...

Purinergic control of vascular tone in the retina.

Purinergic control of vascular tone in the CNS has been largely unexplored. This study examines the contribution of endogenous extracellular ATP, acting on vascular smooth muscle cells, in controlling vascular tone in the in vivo rat retina. Retinal vessels were labelled by i.v. injection of a fluorescent dye and imaged with scanning laser confocal microscopy. The diameters of primary arteriole...

Control of coronary vascular tone by nitric oxide.

A specific difference-spectrophotometric method was used to measure nitric oxide (NO) release into the coronary effluent perfusate of isolated, constant-flow-perfused guinea pig hearts. Authentic NO applied into the coronary circulation decreased vascular resistance dose dependently and enhanced coronary release of cyclic GMP (cGMP) fivefold. Increasing oxygen tension in aqueous solutions from ...

Evidence for direct control of coronary vascular tone by oxygen.