Krebs Memorial Fund 2022 awardees

The Biochemical Society is proud to offer the Krebs Memorial Scholarship commemorate life and work of Sir Hans Krebs, FRS (1900–1981). was a pioneer in study cellular respiration, notably earning Nobel Prize Physiology or Medicine 1953 for discovery citric acid cycle, originally published Journal. also recipient our own Frederick Gowland Hopkins Lecture (now known as Centenary Award) 1961.The Fund set up 1982 response generous contributions Han’s pupils colleagues, with aim reward exceptional academic distinction outstanding promise. usually open applicants any nationality planning PhD biochemistry an allied biomedical science. However, owing disruptions caused by pandemic, we are delighted expand support 2022 include those who have already started their well. For first time history Fund, award scholarships three individuals 2022–2023 year. Find out more about winners below:Science has always engrossed me, especially biology, which triggering my curiosity. I special interest cancer molecular mechanisms pathways, understanding these enables us create powerful therapies.I studied Bachelor Pharmacy degree graduated 2011 from Damascus University Syria, had biochemistry, biotechnology biology. got highest grade cohort biology module at that time, Bachelor’s thesis cancer. After graduation, worked private pharmacy 5 years, during trying be accepted Master’s degree. This difficult due political discrimination but after 2016 pursue Pharmaceutical Analytical Chemistry MSc. determination learn favourite fields (biomedicine biotechnology) won Erasmus Exchange Italy year L’Aquila where wonderful experience because international environment.In September 2020, medical Eastern Piedmont Italy. allowed me acquire advanced knowledge neoplastic disorders functional genomics. In fact, focus apoptosis autophagy, since doing Molecular Pathology laboratory Professor Ciro Isidoro. It great chance under mentorship such scientist beside other lab supervisors mates, taught how think scientifically critically, alongside vital techniques learnt, genetic manipulation 3D cell culture, imaging analysis death. end July honoured spent within highly professional diverse environment.Fortunately, then Liverpool UK, been dreaming live whole life. applied Institute Systems, Integrative Biology, Sonia Rocha’s laboratory, matched passions. important turning point when she position, am extremely grateful her. will research hypoxia changes balance between autophagy different types 2D cultures involvement microenvironment. hope solve part puzzle reveal possible targets future therapies.My self-funded; therefore, searched on internet find scholarship UK. found Foundation luckily honour being accepted. would like thank all members Grants team choosing Lucy Ollett her friendly communication, member Society.DNA key life, even decades sequencing human genome, vast majority it remains unknown. Once labelled ‘junk DNA’, non-coding genome one next frontiers explored responsible estimated 90% disease-causing mutations yet discovered genome. Findings Imbeault Lab (University Cambridge), studying PhD, recently broadened player this region, Krüppel Associated Box Zinc Finger Proteins (KZFPs), large family proteins bind specific sequences DNA, silence transposable elements, diversity mechanisms, regulating cycles genes ‘on’ ‘off’. established KZPFs components rewiring gene regulation impact critical biological processes (e.g., immune responses cognitive functionality). many functions broader implications KZFPs remain unknown, explore breadth characterizing identifying roles inflammation, function disease susceptibility.This aims elucidate dynamic relationships regard inflammatory responses, well interactions influence immunity health overall. CRISPR used mutate lymphoid neutrophil lines, while, e.g., shRNA may employed down-regulate expression primary cells. Additionally, transcriptomic analyses using RNA-Seq epigenetic ChIP-Seq indicate what turned ‘off’ help identify binding sites DNA-associated proteins. These parameters assayed courses reagents trigger toll-like receptors induce programs.Through research, contribute new body knowledge, pushing boundaries currently hundreds impacts. turn, advance current onset progression diseases ultimately treatment options therapy) affected KZFP-related inflammation.I awarding Scholarship, along Dr Michael Department Genetics Cambridge giving opportunity research. Having suffered severe issues very aware can every aspect result, incredibly motivated area day aiding efforts alleviate suffering struggle conditions originating regions.I grew Devon southwest England eight children family. did relatively school began A-levels became deeply interested read free time. completing A-levels, went BSc Biology Durham huge topics professors. While Durham, signalling, opportunities take scientific took two projects while sequence eDNA focussed nuclear envelope through microscopy. greatly enjoyed both experiences pleased awarded Summer Studentship British Cell work. My cemented aspiration complete gave needed follow goal.During final program Oxford thrilled into Clive Wilson’s exosome signalling. Exosomes unique class extracellular vesicle, regulate some fascinating signalling including immunomodulation, development neurodegeneration. core aspects poorly understood, largely limitations experimental methods. therefore excited begin Wilson developed Drosophila model allows live-cell, ex vivo biogenesis place combine novel system protein-based biochemical cells answer fundamental questions biology.Unfortunately, however, October 2020 plans were soon disrupted COVID-19 pandemic. initially able schedule lucky supportive supervisor; significant delays particular, despite promising findings model, accompanying proteomic experiments not begin.I Scholarship. give carry so understand involved forming pathway its potential links allowing exclusively means possibilities further dissect system.To visit website https://www.biochemistry.org/grants-and-awards/grants-and-bursaries/krebs-memorial-scholarship/