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The 2011 United Nations (UN) General Assembly Political Declaration on Prevention and Control of Non-Communicable Diseases (NCDs) brought NCDs to the global health agenda. Essential medicines are central to treating chronic diseases such as hypertension and diabetes. Our study aimed to quantify access to essential medicines for people with chronic conditions in five lowand middle-income countri...
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Motivation: Computational models of biological signalling networks, based on ordinary differential equations (ODEs), have generated many insights into cellular dynamics, but the model-building process typically requires estimating rate parameters based on experimentally observed concentrations. New proteomic methods can measure concentrations for all molecular species in a pathway; this creates...
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The monocyte has been perceived as a relatively inactive member of the monocyte /macrophage series, i.e., a cell in transport to an anatomic site where differentiation to the macrophage will occur. Modification of this perception is meri ted in light of the ready capacity of monocytes, as well as their tissuelocalized progeny, the elicited macrophage, to initiate and propagate coagulation prote...
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Since its identification in 2000, sulfotransferase (SULT) 4A1 has presented an enigma to the field of cytosolic SULT biology. SULT4A1 is exclusively expressed in neural tissue, is highly conserved, and has been identified in every vertebrate studied to date. Despite this singular level of conservation, no substrate or function for SULT4A1 has been identified. Previous studies demonstrated that ...
متن کاملMarkus Storvik
Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists, such as dizocilpine (MK-801) and memantine, bind to the NMDA receptor channel, and block Ca influx. The increase in intracellular concentration of second messengers, such as Ca and cyclic adenosine monophosphate (cAMP), activate the transcription of certain genes. This process is controlled by cAMP response element binding protein ...
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ژورنال
عنوان ژورنال: KENOSIS: Jurnal Kajian Teologi
سال: 2019
ISSN: 2656-4483,2460-6901
DOI: 10.37196/kenosis.v5i1.57