Knockdown resistance mutations predict DDT resistance and pyrethroid tolerance in the visceral leishmaniasis vector Phlebotomus argentipes

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Knockdown resistance mutations predict DDT resistance and pyrethroid tolerance in the visceral leishmaniasis vector Phlebotomus argentipes

BACKGROUND Indoor residual spraying (IRS) with DDT has been the primary strategy for control of the visceral leishmaniasis (VL) vector Phlebotomus argentipes in India but efficacy may be compromised by resistance. Synthetic pyrethroids are now being introduced for IRS, but with a shared target site, the para voltage-gated sodium channel (VGSC), mutations affecting both insecticide classes could...

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Measures to Control Phlebotomus argentipes and Visceral Leishmaniasis in India

Visceral leishmaniasis is a deadly parasitic disease that is transmitted via the bite of a female sand fly, Phlebotomus argentipes. The highest burden of this disease is in northern India. In 2005, India embarked on an initiative with Nepal, Bangladesh, and the World Health Organization to eliminate visceral leishmaniasis by 2015. With the goal of 1 case in 10,000 people still unmet, it is prud...

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The Pyrethroid Knockdown Resistance

New promising insect control efforts are now being evaluated such as biological alternatives or even transgenic insects and Wolbachia based strategies. Although it is increasingly clear that successful approaches must involve integrated actions, chemical insecticides unfortunately still play a central role in pest and vector control (Raghavendra et al., 2011). Development of new safe and effect...

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measures to control phlebotomus argentipes and visceral leishmaniasis in india

visceral leishmaniasis is a deadly parasitic disease that is transmitted via the bite of a female sand fly, phlebotomus argentipes. the highest burden of this disease is in northern india. in 2005, india embarked on an initiative with ne­pal, bangladesh, and the world health organization to eliminate visceral leishmaniasis by 2015. with the goal of 1 case in 10,000 people still unmet, it is pru...

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Insecticide susceptibility status of Phlebotomus argentipes, a vector of visceral leishmaniasis in different foci in three states of India.

BACKGROUND & OBJECTIVES Phlebotomus argentipes is the vector for visceral leishmaniasis in India. The development of resistance in kala-azar vector to DDT has been reported from various parts of India. The main objective of this study was to generate information on insecticides susceptibility status of P. argentipes to DDT, malathion and deltamethrin in different parts in three states of India....

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ژورنال

عنوان ژورنال: PLOS Neglected Tropical Diseases

سال: 2017

ISSN: 1935-2735

DOI: 10.1371/journal.pntd.0005504