KN-93 inhibits IKr in mammalian cardiomyocytes

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KN-93 inhibits IKr in mammalian cardiomyocytes.

Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93 is widely used in multiple fields of cardiac research especially for studying the mechanisms of cardiomyopathy and cardiac arrhythmias. Whereas KN-93 is a potent inhibitor of CaMKII, several off-target effects have also been found in expression cell systems and smooth muscle cells, but there is no information on the KN93 si...

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ژورنال

عنوان ژورنال: Journal of Molecular and Cellular Cardiology

سال: 2015

ISSN: 0022-2828

DOI: 10.1016/j.yjmcc.2015.10.012