KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

The mammalian circadian timing system and metabolism are highly interconnected, disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) transcription that govern metabolic homeostasis in various organs. Many KLFs show a expression the liver. Here, we loss clock-controlled KLF10 hepatocytes results extensive reprogramming mouse liver transcriptome, which turn alters temporal coordination pathways energy metabolism. We also glucose fructose induce Klf10, helps mitigate intolerance hepatic steatosis mice challenged sugar beverage. Functional genomics further reveal target genes primarily involved central carbon Together, these findings integrates metabolism-related signaling, serves as transcriptional brake protects against deleterious effects increased consumption.