Kleinhovia Hospita Leaf Extract Protects the Heart Against Infarction by Isoproterenol

Background: Isoproterenol, a β-adrenergic agonist, may induce myocardial infarction when used in high dosage rats. This study was conducted to evaluate the effect of ethanol extract Kleinhovia hospita leaves on cardiac biomarkers and structures rats induced by isoproterenol. Methods: Male (n=30) were assigned as normal controls or treatment groups. The groups received pretreatments, either placebo at doses 250, 500, 750 mg/kg for 14 days, followed two isoproterenol injections 100 mg/kg. After 24 hours, blood samples taken hearts dissected. tested creatinine kinase band (CKMB) lactate dehydrogenase (LDH). Heart histopathology analysis performed staining with hematoxylin eosin. Results: significantly increased CKMB LDH levels group compared those controls. Pretreatment 500 reduced serum placebo. histopathological examinations showed presence diffused necrosis severe inflammation group. tissue damages Conclusion: K. infarctions rats’ heart tissue, shown low LDH, necrotic lesions rat pretreatment.