منابع مشابه
Kinome Profiling
The use of arrays in genomics has led to a fast and reliable way to screen the transcriptome of an organism. It can be automated and analysis tools have become available and hence the technique has become widely used within the past few years. Signal-transduction routes rely mainly on the phosphorylation status of already available proteins; therefore kinases are central players in signal-trans...
متن کاملKinome profiling of clinical cancer specimens.
Over the past years novel technologies have emerged to enable the determination of the transcriptome and proteome of clinical samples. These data sets will prove to be of significant value to our elucidation of the mechanisms that govern pathophysiology and may provide biological markers for future guidance in personalized medicine. However, an equally important goal is to define those proteins...
متن کاملKinome profiling for uncovering the molecular mode of pharmacon action
Defining the molecular effects of compounds with clinically useful properties remains exceedingly challenging if no a priori assumptions can be made as to the biochemical details of the biological effect observed. We set out to identify the molecular target of violacein, a purple-coloured pigment produced by the Amazon River Chromobacterium violaceum, which is used by indigenous Indians in the ...
متن کاملHuman kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
Human cytomegalovirus (HCMV) modulates numerous cellular signaling pathways. Alterations in signaling are evident from the broad changes in cellular phosphorylation that occur during HCMV infection and from the altered activity of multiple kinases. Here we report a comprehensive RNAi screen, which predicts that 106 cellular kinases influence growth of the virus, most of which were not previousl...
متن کاملStrategies for kinome profiling in cancer and potential clinical applications: chemical proteomics and array-based methods.
Kinases are key enzymes involved in deregulated signal transduction associated with cancer development and progression. The advent of personalized medicine drives the development of new diagnostic tools for patient stratification and therapy selection Ginsburg and Willard (Transl Res 154:277-287, 2009). Since deregulation of kinase-mediated signal transduction is implied in tumorigenesis, the a...
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ژورنال
عنوان ژورنال: Scientifica
سال: 2012
ISSN: 2090-908X
DOI: 10.6064/2012/306798