Kinetics of receptor occupancy during morphogen gradient formation
نویسندگان
چکیده
منابع مشابه
Kinetics of receptor occupancy during morphogen gradient formation.
During embryogenesis, sheets of cells are patterned by concentration profiles of morphogens, molecules that act as dose-dependent regulators of gene expression and cell differentiation. Concentration profiles of morphogens can be formed by a source-sink mechanism, whereby an extracellular protein is secreted from a localized source, diffuses through the tissue and binds to cell surface receptor...
متن کاملKinetics of morphogen gradient formation.
In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg. To understand how the range is controlled, we measured the four key kinetic parameters governing morphogen spreading: the production rate, the effective diffusion coefficient, the degradation ...
متن کاملMorphogen gradient formation.
How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then...
متن کاملSpatially distributed morphogen production and morphogen gradient formation.
Partial diferential equations and auxiliary conditions governing the activities of the morphogen Dpp in Drosophila wing imaginal discs were formulated and analyzed as Systems B, R, and C in [7] [9] [10]. All had morphogens produced at the border of anterior and posterior chamber of the wing disc idealized as a point, line, or plane in a one-, two-, or three-dimensional model. In reality, morpho...
متن کاملReaction-subdiffusion model of morphogen gradient formation.
We study gradient formation of subdiffusive morphogens. The morphogens are produced at a source point at a constant rate. From there they move subdiffusively and are also subject to degradation at a rate that may depend on location and on time. Our analysis is based on a reaction-subdiffusion equation obtained from a continuous time random-walk model with a long-tailed waiting time distribution...
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ژورنال
عنوان ژورنال: The Journal of Chemical Physics
سال: 2013
ISSN: 0021-9606,1089-7690
DOI: 10.1063/1.4811654