Kinetics of Odorant Recognition with a Graphene-Based Olfactory Receptor Mimicry

Malaria vector mosquito species rely on a handful of specific pheromones for mating; one them, sulcatone (6-methyl-5-hepten-2-one), is also found in human exudation. Therefore, complete understanding the insect’s olfaction, and rapid real-time methods odorant detection, are required. Here, we mimic recognition nerve cells an antenna with synthetic graphene-based bio-electro-interfacial receptor. By this means, obtain kinetics genuine reaction compare them to electro-antennogram data that represent more complex scenario living insect. The odorant-binding proteins OBP 9A 9B only associate their ligands weakly, showing KDs between 2.1 mM 3 mM, while binding depend structural feature cystine knot modulated by local milieu within protein-aided enhancement zone.