Kinetics of Macrolide Action

Kinetics of Macrolide Action

Members of the macrolide class of antibiotics inhibit peptide elongation on the ribosome by binding close to the peptidyltransferase center and blocking the peptide exit tunnel in the large ribosomal subunit. We have studied the modes of action of the macrolides josamycin, with a 16-membered lactone ring, and erythromycin, with a 14-membered lactone ring, in a cell-free mRNA translation system ...

Kinetics of macrolide action: the josamycin and erythromycin cases.

Members of the macrolide class of antibiotics inhibit peptide elongation on the ribosome by binding close to the peptidyltransferase center and blocking the peptide exit tunnel in the large ribosomal subunit. We have studied the modes of action of the macrolides josamycin, with a 16-membered lactone ring, and erythromycin, with a 14-membered lactone ring, in a cell-free mRNA translation system ...

Kinetics of Phosphoglucomutase Action*

The mechanism of activation of the phosphoglucomutase reaction by the coenzyme, cu-glucose 1,6-diphosphate, was studied by Leloir et al. (1)) Sutherland et al. (2)) and Jagannathan and Luck (3). In 1954, Najjar and Pullman (4) showed that the active, phosphorylated form of the enzyme interacted with glucose l-phosphate to form the coenzyme and the inactive, dephosphorylated enzyme, and that the...

Cholinomimetic action of macrolide antibiotics on airway gland electrolyte secretion.

We investigated the acute effects of erythromycin (EM) and its derivatives on ionic currents in airway glands from feline tracheae. Therapeutic concentrations of EM or clarithromycin (CAM) attenuated the whole cell currents evoked by ACh in a competitive manner. The maximally stimulated inward Cl-currents were reduced to 54 and 83% and the outward K+ currents to 55 and 84% of control values by ...

Reducible Mass-Action Chemical Kinetics Systems