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The heterogenous nature of breast tumours (Hawkins et al., 1977; Silfversward et al., 1980) complicates the application of oestrogen receptor assay results to the management of breast cancer. Much effort has therefore been expended on the development of histochemical assays to detect receptors in tissue sections, initially with oestrogenprotein conjugates (e.g. Pertschuk et al., 1979; Lee, 1978...

Healthy Kids

Kids observing other kids' hands: visuomotor priming in children.

We investigated motor resonance in children using a priming paradigm. Participants were asked to judge the weight of an object shortly primed by a hand in an action-related posture (grasp) or a non action-related one (fist). The hand prime could belong to a child or to an adult. We found faster response times when the object was preceded by a grasp hand posture (motor resonance effect). More cr...

Cohort Profile: The Applied Research Group for Kids (TARGet Kids!).

The Applied Research Group for Kids (TARGet Kids!) is an ongoing open longitudinal cohort study enrolling healthy children (from birth to 5 years of age) and following them into adolescence. The aim of the TARGet Kids! cohort is to link early life exposures to health problems including obesity, micronutrient deficiencies and developmental problems. The overarching goal is to improve the health ...

Kids at Risk

Sir-We believe, like Dr Cosolo and colleagues, that studies of the pharmacokinetics and metabolism of cytotoxic drugs will yield important information on the relationship between these variables and the clinical effects of response and toxicity. At present we are conducting pharmacokinetic and metabolic studies on a number of cytotoxic drugs. In the study we described, methotrexate pharmacokine...