Ki-67 expression in early prostate cancer and associated pathological lesions.
نویسندگان
چکیده
منابع مشابه
Immunohistochemical analysis of Ki-67 expression in oral lichen planus lesions
Introdouction: Lichen planus is a chronic, relatively common, dermal mucosa disease. The World Health Organization (WHO) has introduced lichen planus as a premalignant condition. Ki-67 is a protein that can be detected in all active phases of the cell cycle, especially in the G2 and M phases. Considering the major role of Ki-67 in the regulation of the cell cycle and the fact that it is one of ...
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Background: The characteristics of the cellular kinetic reflect the aggressiveness of the tumors and even their prognosis, many studies proving the correlation between the increased proliferation activity and a poor prognosis in a variety of neoplasms. Aim: The analysis of immunohistochemical Ki-67 expression in 55 patients with gastric cancer, the correlation with clinico-pathological factors ...
متن کاملQuantifying the Ki-67 Heterogeneity Profile in Prostate Cancer
73 Background: Ki-67 is a robust predictive/prognostic marker in prostate cancer however tumor heterogeneity may compromise its clinical utility when Ki-67 is determined off of prostate biopsy samples. We examined the variation of Ki-67 in prostate biopsy samples by NCCN risk groups and the location of the highest Ki-67 relative to the most dominant lesion on multiparametric (MP) MRI. METHODS...
متن کاملKi-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia.
OBJECTIVE Ki-67 is a proliferation-associated nuclear antigen and is expressed in all cycling cells except for resting cells in the G0-phase. PCNA is an acidic nuclear protein and has been recognized as a histologic marker for the G1/S phase in the cell cycle. Ki-67and PCNA labeling indices are considered to reflect cell proliferation, particularly, growth fraction. The purpose of this study is...
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MIB-1 is a marker expressed only in proliferating cells. The aim of this study was to evaluate MIB-1 (Ki-67) labeling index in primary prostate cancer and matched nodal metastases for its prognostic value. Forty radical prostatectomy specimens from 2008 to 2009 were randomly selected for this study. Tumor blocks were immunostained using the monoclonal antibody MIB-1 (Dakorp. Denmark). MIB-1 exp...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1996
ISSN: 0021-9746
DOI: 10.1136/jcp.49.9.741