Ketamine cystitis—A long-lasting burning issue in Taiwan

Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine.

BACKGROUND It has been reported that mu-opioid receptor activation leads to a sustained increase in glutamate synaptic effectiveness at the N-methyl-D-aspartate (NMDA) receptor level, a system associated with central hypersensitivity to pain. One hypothesis is that postoperative pain may result partly from the activation of NMDA pain facilitatory processes induced by opiate treatment per se. Th...

PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine

Yueju confers antidepressant effects in a rapid and long-lasting manner, similar to ketamine. CREB (cAMP-response element binding protein) signaling is implicated in depression pathology and antidepressant responses. However, the role of CREB and associated brain derived neurotrophic factor (BDNF) signaling in rapid and long-lasting antidepressant effects remains unclear. Here, we demonstrated ...

Ketamine produces lasting disruptions in encoding of sensory stimuli.

The current study analyzed the acute, chronic, and lasting effects of ketamine administration in four inbred mouse strains (C3H/HeHsd, C57BL/6Hsd, FVB/Hsd, and DBA/2Hsd) to evaluate vulnerability to ketamine as a drug of abuse and as a model of schizophrenia. Serum half-life of ketamine was similar between all strains (approximately 13 min). Also, the ratio of brain-to-serum ketamine levels was...

Long - lasting , long - range detection

We examined the time course of threshold reduction in the Gabor lateral masking paradigm (Polat and Sagi 1993). Contrast detection thresholds were measured (2AFC) for a brieey presented (36 msec) foveal Gabor signal (GS), preceded by a presentation (90 msec) of two high-contrast GS anked masks, with Stimulus Onset Asynchrony (SOA) varying from 0 to 16,290 msec. Using target-to-mask separations ...

Ventricular tachycardia: is it a burning issue?