Ketamine but not glycine potentiates antidepressant like action of citalopram in mice exposed to chronic mild stress

Background: The present study was designed to investigate the effect of citalopram, ketamine, glycine and their combinations on animal models depression. Methods: Swiss Albino male mice were subjected chronic mild stress for 6 weeks inducing depression, randomly divided into different groups: citalopram (5 10 mg/kg), ketamine (17.5 35 (50 100 mg/kg) + mg/kg). Two behavioural tests utilized assessment namely tail suspension test (TST) forced swim (FST). Immobility time recorded min, before after administration drug. Results: Citalopram (10 caused significant decrease in immobility TST model only but not FST. insignificant both models. Moreover, combination with significantly reduced Glycine at a dose mg/kg (but 50 increased as compared control group. Further, when administered increase paradigms, though insignificant. Conclusions: Ketamine demonstrated antidepressant like action FST it potentiated that might be due role NMDA receptors.