منابع مشابه
Keeping carbon dioxide in check
The response of the brainstem to increased levels of carbon dioxide in the blood is coordinated with the response of the cardiovascular system.
متن کاملCentrosomes: Keeping Tumors in Check
Centrosomal abnormalities have been observed in a wide range of tumors, but it is not clear whether these abnormalities alone can induce cancer formation or whether they are a consequence of cancer progression. Recent work in Drosophila suggests that centrosome defects in asymmetrically dividing cells can induce tumors at a higher frequency than other conditions known to cause genomic instability.
متن کاملKeeping EGFR signaling in check
The discovery of multiple entry and trafficking routes within cells has changed the classical view of endocytosis: once thought to be a simple one-way mechanism to downmodulate plasma membrane (PM) signaling, it is now considered to be a network of intricate and interconnected highly regulated pathways, which allows the resolution of receptor-originated signals in space and time. In addition to...
متن کاملDesigning E1 Deleted Adenoviral Vector by Homologous Recombination
Adenoviruses are used extensively to deliver genes into mammalian cells, particularly where there is a requirement for high-level expression of transgene products in cultured cells, or for use as recombinant viral vaccines or in gene therapy. In spite of their usefulness, the construction of adenoviral vectors (AdV) is a cumbersome and lengthy process that is not readily amenable to the generat...
متن کاملHomologous recombination
DNA damage, in the form of DNA double-strand breaks, poses a considerable threat to genomic integrity and cell survival. If left unrepaired, a single double-strand break is sufficient to cause cell death and, if repaired inappropriately, a double-strand break may give rise to a potentially oncogenic translocation. Double-strand breaks in genomic DNA may arise accidentally in a number of ways, i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Research
سال: 2016
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2016.25