KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity
نویسندگان
چکیده
منابع مشابه
Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking
The slow delayed-rectifier potassium current (IKs) is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to hereditary long QT syndrome types 1 and 5, respectively. It is widely recognised that the KCNQ1/KCNE1 (Q1/E1) channel requires phosphatidylinosi...
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The voltage-gated KCNQ1 potassium channel is expressed in cardiac tissues, and coassembly of KCNQ1 with an auxiliary KCNE1 subunit mediates a slowly activating current that accelerates the repolarization of action potential in cardiomyocytes. Mutations of KCNQ1 genes that result in reduction or loss of channel activity cause prolongation of repolarization during action potential, thereby causin...
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متن کاملSingle-channel mechanosensitive currents.
Morris and Horn (1) describe ion channel activity, elicited by mechanical stimulation, in both membrane patches and in whole neurons from the snail Lymnaea stagnalis. In whole-cell recordings, mechanical stimulation did not elicit the large macroscopic mechanosensitive currents (IMs) that were anticipated from studies of single mechanosensitive (MS) channels in membrane patches. These negative ...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2019
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.28013