Kaposi's Sarcoma and Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8): Where Are We Now?
نویسندگان
چکیده
منابع مشابه
[Human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus].
Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray contai...
متن کاملKaposi’s Sarcoma and Kaposi’s Sarcoma-associated Herpesvirus/Human Herpesvirus 8: An Overview
Kaposi’s sarcoma (KS) is a vascular tumor that was brought to the attention of the medical community over a century ago in a fascinating case series in which purple-coloured nodular skin lesions were observed on five elderly men, with widespread cutaneous and visceral involvement reported in one patient at autopsy (Kaposi, 1872 as cited in Ober, 1988). This ‘Classic’ variant of KS is rare and t...
متن کاملKaposis sarcoma in a Nairobi hospital.
BACKGROUND Kaposi's sarcoma (KS) is associated epidemiologically with HIV infection and a number of countries have reported a dramatic increase in the incidence of KS with the advent of AIDS. Although AIDS is prevalent in Kenya, no studies on the impact of AIDS on the pattern of KS has been carried out. OBJECTIVE To determine any changes in the pattern of KS that might have occurred since the...
متن کاملKaposi Sarcoma-Associated Herpesvirus
Kaposi sarcoma-associated herpesvirus (KSHV) is known to be a human carcinogen based on sufficient evidence from studies in humans. This conclusion is based on evidence from epidemiological and molecular studies, which show that KSHV causes Kaposi sarcoma, primary effusion lymphoma, and a plasmablastic variant of multicentric Castleman disease, and on supporting mechanistic data. KSHV causes ca...
متن کاملVirology, pathogenetic mechanisms, and associated diseases of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8).
Kaposi sarcoma-associated herpesvirus (KSHV) is a recently discovered and characterized member of the herpesvirus family. It is one of a few viruses proved to be associated with tumorigenesis in humans. Its causal association with 4 clinical and epidemiologic variants of Kaposi sarcoma (classic, endemic, iatrogenic, and acquired immunodeficiency virus-associated) as well as with several lymphop...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1997
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/89.24.1829