Kaposi sarcoma

A 47-year-old heterosexual man with history of intravenous (IV) methamphetamine use presented to the Emergency Department dyspnea and raised lesions throughout his arms, legs, chest as depicted in Figure 1. Biopsy a right leg lesion demonstrated atypical vascular proliferation within dermis producing slit-like/irregular architecture consistent Kaposi sarcoma. Human herpesvirus 8 (HHV-8) staining was HIV-1 antibody testing positive patient had an absolute CD4 count 19. sarcoma is relatively rare United States antiretroviral therapy has become more accessible. The appearance tumor inflammation mucosal involvement should raise suspicion for HHV-8.