Kalanchoe Pinnata aqueous extract has the potential to improve haematological profile and fatigue status of mice subjected to Free Swimming Endurance Test

Introduction: Kalanchoe pinnata extracts have been shown to possess beneficial cardiovascular effects, analgesic and myorelaxant activities. This study aimed at evaluating the haematological anti-fatigue effects of its aqueous extract. Materials methods: was an in vivo pharmacological experiment, carried out Laboratory Zoology, University Buea, from January May 2018. A total 48 mice were subjected a 90mins/day-free endurance swimming test for 14 days. Two groups received distilled water 12% NaCl solution, respectively. Five plant extract (25, 50, 100 200 mg/kg/day) 200mg/kg/day+NaCl. One positive control group 5% Vitamin C (1.97mg/kg/day). All administrations by gavage. Maximum time, glycaemia, lactatemia, uremia, triglyceridemia, indices, tissue glutathion peroxidase, malondialdehyde, glucose creatine kinase-MB heart or gastrocnemius muscle measured. Results: K. (50 100mg/kg/day) induced non-significant increase duration, compared neutral control. However, 12%NaCl recorded significant (P<0.05) increase. In blood, decrease platelets that significantly reverted 200mg/kg+NaCl group. The prevented level CK-MB decreased serum triglycerides, glucose, urea nitrogen Lactate levels. tissues, MDA levels increased (P<0.001) negative These increases (200mg/kg/day). Conclusions: Significant biochemical variations support hypothesis could be used delay exercise fatigue.