KAISO, a critical regulator of p53-mediated transcription ofCDKN1Aand apoptotic genes
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چکیده
منابع مشابه
KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.
An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. In this study, we show that KAISO is induced by DNA damage in p53-expressing cells and then interact...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1318780111