K+-Cl−co-transporter 2 (KCC2) – a membrane trafficking perspective
نویسندگان
چکیده
منابع مشابه
K/Cl cotransporter KCC2 membrane trafficking and functionality is regulated by transforming growth factor beta 2
Functional activation of the neuronal K-Cl-cotransporter KCC2 is a prerequisite for shifting GABAA responses from depolarizing to hyperpolarizing during development. Here we introduce transforming growth factor beta 2 (TGF-2) as a novel regulator of KCC2 membrane trafficking and functional activation. TGF-2 controls membrane trafficking, surface expression and activity of KCC2 in developing a...
متن کاملThe membrane trafficking and functionality of the K+-Cl− co-transporter KCC2 is regulated by TGF-β2
Functional activation of the neuronal K(+)-Cl(-) co-transporter KCC2 (also known as SLC12A5) is a prerequisite for shifting GABAA responses from depolarizing to hyperpolarizing during development. Here, we introduce transforming growth factor β2 (TGF-β2) as a new regulator of KCC2 membrane trafficking and functional activation. TGF-β2 controls membrane trafficking, surface expression and activi...
متن کاملActivity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
The neuronal K/Cl transporter KCC2 exports chloride ions and thereby influences the efficacy and polarity of GABA signaling in the brain. KCC2 is also critical for dendritic spine morphogenesis and the maintenance of glutamatergic transmission in cortical neurons. Because KCC2 plays a pivotal role in the function of central synapses, it is of particular importance to understand the cellular and...
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Using antibodies prepared against a unique region (exon 22-24) of rat K(+)-Cl(-) cotransporter-2 (KCC2), we confirmed that the ~140-kDa KCC2 protein is exclusively expressed in rat brain, but in chicken, we observed strong reactivity not only with the ~140-kDa KCC2 protein in brain but also a slightly larger ~145-kDa protein in heart. In silico analysis showed that while exon 22 of KCC2 is uniq...
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The trafficking of synaptic proteins is unquestionably a major determinant of the properties of synaptic transmission. Here, we present a detailed analysis of the downregulation and intracellular trafficking of the cocaine- and amphetamine-sensitive dopamine transporter (DAT), a presynaptic plasma membrane protein responsible for the regulation of extracellular DA concentrations. Using PC12 cel...
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ژورنال
عنوان ژورنال: Molecular Membrane Biology
سال: 2016
ISSN: 0968-7688,1464-5203
DOI: 10.1080/09687688.2017.1393566