Juxtaglomerular Cells in the Teleost Kidneys

Immunohistochemical demonstration of juxtaglomerular cells in the kidneys of domestic mammals and fowls.

Juxtaglomerular cells.

• Because juxtaglomerular (JG) cells are sprinkled throughout the renal cortex, just as beta cells are sprinkled throughout the exocrine pancreas, the classical extirpation and substitution approach in endocrinology is a limited means for the study of their function. Until they can be isolated and pure extracts made, or until an "alloxan" for JG cells is discovered, their study will depend chie...

The Granulation of Juxtaglomerular Cells

The pathogenesis of renal hypertension remains a mystery. Renal disease can be severe enough to produce terminal uremia without producing hypertension. On the other hand, hypertension can be induced by partial constriction of the renal artery, and the kidney in question may retain good excretory function. The excretory activities of the kidney seem not to be directly related to its hypertensive...

Electrophysiology of the renin-producing juxtaglomerular cells.

Renin is an aspartyl-proteinase hormone that is produced, stored and released by juxtaglomerular (JG) granular cells in the distal part of the renal afferent arterioles. The rate of secretion of renin from JG cells is one of the main determinants of the overall activity of the renin-angiotensin system, and is the most well regulated parameter of all constituents of that system. At least three c...

Studies on Renal Juxtaglomerular Cells

Accumulation of granules in the juxtaglomerular cells occurred in rats which were maintained for 5 to 6 weeks on a diet low in sodium, chloride. Cytological evidence suggests that this was probably a storage phase of secretion following a decrease in the rate of liberation of the granules. Administration of DCA (desoxycorticosterone acetate) to salt-deficient rats did not alter this appearance ...