منابع مشابه
Jumonji and cardiac fate.
C onsiderable information is known about the extracellular signals that drive pluripotent stem cells (PSCs) through a stepwise program to become cardiomyocytes. An article by Ohtani et al in this issue links extrinsic signals to histone demethylation needed to form mesoderm, the first step in cardiogenesis. Extrinsic signals drive the stepwise differentiation of PSCs into cardiomyocytes, and hi...
متن کاملmicroRNAs and Cardiac Cell Fate
The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their role in controlling the different pathways regulating cell identity and fate det...
متن کاملTranscriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration.
RATIONALE Neonatal mice have the capacity to regenerate their hearts in response to injury, but this potential is lost after the first week of life. The transcriptional changes that underpin mammalian cardiac regeneration have not been fully characterized at the molecular level. OBJECTIVE The objectives of our study were to determine whether myocytes revert the transcriptional phenotype to a ...
متن کاملFate of the mammalian cardiac neural crest.
A subpopulation of neural crest termed the cardiac neural crest is required in avian embryos to initiate reorganization of the outflow tract of the developing cardiovascular system. In mammalian embryos, it has not been previously experimentally possible to study the long-term fate of this population, although there is strong inference that a similar population exists and is perturbed in a numb...
متن کاملCharacterization of the human jumonji gene.
While constructing a cDNA library of human embryos, we have isolated a clone homologous to jumonji, a mouse gene required for neural tube formation. We have determined the complete coding sequence of the human homologue (JMJ) and deduced the amino acid sequence of the putative protein. We show here that human and mouse jumonji putative proteins are homologous and present 90% identity. During hu...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.113.302202