John Leslie Turk

JOHN F . ENGELHARDT , LESLIE LITZKY , and

Recombinant adenoviruses have tremendous potential for gene therapy of cystic fibrosis (CF) lung disease. First-generation recombinant viruses, rendered replication defective by deleting EI, have been associated with high-level recombinant gene expression in airway epithelial cells when administered directly to the lung. Experience in mice and non-human primates indicates that transgene express...

John Leslie King Kalle Lyytinen University of Michigan Case Western Reserve University Editorial Board

This paper addresses the formation of standards in business-to-business (B2B) e-commerce. The contrast between the developing of generic standards and sector specific standards is considered and the argument that users will commit to developing sectoral standards while IT vendors will direct their resources to generic standards is restated. Specifically, the emergence of the OASIS committee dev...

Evolvability LESLIE

Living organisms function in accordance with complex mechanisms that operate in different ways depending on conditions. Darwin’s theory of evolution suggests that such mechanisms evolved through variation guided by natural selection. However, there has existed no theory that would explain quantitatively which mechanisms can so evolve in realistic population sizes within realistic time periods, ...

Leslie Matthews

Leslie B. Vosshall

adhesion. We used urushiol, the active ingredient in poison ivy, as an agonist for aggregation. Of course, I never wore anything practical like pants or a lab coat and got a raging urushiol rash all over my legs. When I wasn’t tampering with sea urchin reproduction or dripping urushiol on my thighs, I hung out with students and faculty in the legendary MBL summer courses and went to a lot of gr...