JL 13, An Atypical Antipsychotic: A Preclinical Review

Newer oral atypical antipsychotic agents: a review.

“black-box” warnings for all antipsychotic drugs.2 Antipsychotic agents may be classified in several ways. Commonly, they can be designated as older drugs (often called conventional or “typical” antipsychotics) and newer “atypicals.” The term atypical refers to the perceived lower likelihood of extrapyramidal symptoms, a sequela that had been deemed characteristic of the first generation of ant...

What makes an antipsychotic atypical?

A systematic review of atypical antipsychotic drugs in schizophrenia.

Authors' objectives The main objectives were to assess the clinical effectiveness, safety and cost-effectiveness of 'atypical' antipsychotic drugs in schizophrenia in comparison with conventional antipsychotic drugs, placebo and other atypical antipsychotic drugs. The secondary objectives of the review were to investigate response in those with treatment-resistant schizophrenia, with predominan...

A Review of Metabolic Issues in Atypical Antipsychotic Treatment

Reports of diabetes, diabetic ketoacidosis, hyperglycemia, and dyslipidemias in patients treated with atypical antipsychotics have increased in recent years. This increase has led to growing concern about a possible link between these metabolic effects and atypical antipsychotic therapy. This review article provides an overview of the evidence for an association between glucose and lipid dysreg...

Benzisoxazole derivatives as Atypical Antipsychotic drugs: A Review

Antipsychotic medications constitute a diverse series of heterocyclic compounds that are used to treat psychotic problems, particularly schizophrenia and bipolar affective disorders. Heterocyclic molecules such as benzisoxazole derivatives, especially 3-(piperidin-4-yl)-1,2-benzisoxazole have been widely used as antipsychotic drugs. Atypical antipsychotic drugs which are derived from benzisoxaz...