منابع مشابه
Liver polyploidy: Dr Jekyll or Mr Hide?
Polyploidization is a state in which cells possess more than two sets of homologous chromosomes, which occurs frequently in nature [1]. In Mammals, whole organism polyploidy is usually lethal; however, some tissues develop a certain degree of polyploidy during their normal lifecycle. Polyploid cells are generated because of cell fusion or abnormal cell division (e.g. endoreplication, mitotic sl...
متن کاملJekyll and Hide
Neurodegenerative diseases are a burden of our century. Although significant efforts were made to find a cure or relief to this scourge, their pathophysiology remains vague and the cellular function of the key involved proteins is still unclear. However, in the case of amyloid β (Aβ), a key protein concerned in Alzheimer disease, we are now a step closer in the unscrambling of its cellular func...
متن کاملUric Acid for Cardiovascular Risk: Dr. Jekyll or Mr. Hide?
Uric acid (UA) is a potent endogenous antioxidant. However, high concentrations of this molecule have been associated with cardiovascular disease (CVD) and renal dysfunction, involving mechanisms that include oxidative stress, inflammatory processes, and endothelial injury. Experimental and in vitro results suggest that this biomarker behaves like other antioxidants, which can shift from the ph...
متن کاملRun or Hide? Fixed and Moving Targets
We examine the time it takes for a random walk to hit an adversarial moving target. This problem was introduced by Aldous and Fill as the “cat and mouse” game. They conjectured that for every graph hitting an optimally moving target takes as long in expectation as hitting an optimally placed stationary target. We show this conjecture is false by presenting an instance of a graph where it takes ...
متن کاملActivity cliffs in drug discovery: Dr Jekyll or Mr Hyde?
The impact activity cliffs have on drug discovery is double-edged. For instance, whereas medicinal chemists can take advantage of regions in chemical space rich in activity cliffs, QSAR practitioners need to escape from such regions. The influence of activity cliffs in medicinal chemistry applications is extensively documented. However, the 'dark side' of activity cliffs (i.e. their detrimental...
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ژورنال
عنوان ژورنال: Nature
سال: 2004
ISSN: 0028-0836,1476-4687
DOI: 10.1038/432680a