James Cox’s Silver Swan

Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition.

The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the treatment of inflammation, pain, and cancers. A selective inhibition of the different isoforms, particularly COX-2, is desirable, and consequently a deeper understanding of the molecular basis of selective inhibition is of great demand. Using an advanced computational tec...

James

a chair, he was the very picture of dejection. His small head was hanging, an obstreperous tuft of the coarse, sandy hair standing defiantly upright on the crown of it; his complexion was sallow and pasty, and not in any way enhanced by a sparse scattering of tiny yellow freckles, plainly visible at close view; his generous mouth drooped, like his head, the lips pale, but firmly closed. In his ...

Swan Unilateral Spatial Neglect

Swan song for schizophrenia?

A bad wound will heal but a bad name will kill. —Scottish proverb Schizophrenia is a word that frightens people, is replete with stigma, is used pejoratively in daily speech and is ety-mologically absurd. There is now widespread international interest in In this Editorial, we examine the justification for giving up the term and consider strategies for finding an alternative. In a recent article...

A Swan-like theorem

For purposes of implementing field arithmetic in F2n efficiently, it is desirable to have an irreducible polynomial f(x) ∈ F2[x] of degree n with as few terms as possible. The number of terms must be odd, as otherwise x+1 would be a factor. Often a trinomial x+x+1 can be found, or at least a pentanomial, x+x1 +x2 +x3 +1, where n > m1 > m2 > m3 > 0. If α is a root of f , then {1, α, α, . . . , α...