JAKs and STATs in Immunity, Immunodeficiency, and Cancer
نویسندگان
چکیده
منابع مشابه
JAKs, Stats, and CK2?
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متن کاملJaks, STATs, Cytokines, and Sepsis.
Sepsis remains a significant cause of morbidity and mortality in the intensive care unit (68), affecting more than 500,000 patients per year in the United States (39). The incidence is increasing despite the major advances in the development of antimicrobial agents and other supportive treatments (56). Septic patients often succumb to a systemic inflammatory response, of which multiple organ fa...
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Cytokines have critical functions in regulating immune responses. A large number of these factors bind related receptors termed the Type I and Type II families of cytokine receptors. These receptors activate Janus kinases (Jaks) and Stat family of transcription factors. The essential and specific function of Jaks and Stats is particularly well illustrated by human and mouse mutations. The possi...
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Cytokines that bind to the interleukin-2 (IL-2) receptor common gamma chain (gamma c), including IL-2, IL-4, IL-7, IL-9, and IL-15, are important for the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes. These cytokines have overlapping biological effects that in part result from the use of the shared receptor subunit gamma c. Recently it has b...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2013
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmra1202117