J012 Cyclooxygenase-2-dependent isoprostane production in hypoxia-induced pulmonary hypertension
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منابع مشابه
Pulmonary Circulation and Hypoxia Cyclooxygenase-2 and an early stage of chronic hypoxia-induced pulmonary hypertension in newborn pigs
pigs hypoxia-induced pulmonary hypertension in newborn Cyclooxygenase-2 and an early stage of chronic You might find this additional info useful... physiology, especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a publishes original papers that deal with diverse area of research in applied
متن کاملCyclooxygenase-2 and an early stage of chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Our objective was to determine whether cyclooxygenase (COX)-2-dependent metabolites contribute to the altered pulmonary vascular responses that manifest in piglets with chronic hypoxia-induced pulmonary hypertension. Piglets were raised in either room air (control) or hypoxia for 3 days. The effect of the COX-2 selective inhibitor NS-398 on responses to arachidonic acid or acetylcholine (ACh) w...
متن کاملCyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis.
Exogenous prostacyclin is effective in reducing pulmonary vascular resistance in some forms of human pulmonary hypertension (PH). To explore whether endogenous prostaglandins played a similar role in pulmonary hypertension, we examined the effect of deleting cyclooxygenase (COX)-gene isoforms in a chronic hypoxia model of PH. Pulmonary hypertension, examined by direct measurement of right ventr...
متن کاملIntravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2.
BACKGROUND Pulmonary hypertension induced by chronic hypoxia is characterized by thickening of pulmonary artery walls, elevated pulmonary vascular resistance, and right-heart failure. Prostacyclin analogues reduce pulmonary pressures in this condition; raising the possibility that cycloxygenase-2 (COX-2) modulates the response of the pulmonary vasculature to hypoxia. METHODS AND RESULTS Sprag...
متن کاملEffect of thoracic epidural blockade on hypoxia-induced pulmonary arterial hypertension in rats
Objective(s): The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Materials and Methods: Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the t...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases
سال: 2009
ISSN: 1875-2136
DOI: 10.1016/s1875-2136(09)72387-3