Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction
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چکیده
منابع مشابه
Effect of CYP3A perpetrators on ibrutinib exposure in healthy participants
Ibrutinib (PCI-32765), a potent covalent inhibitor of Bruton's tyrosine kinase, has shown efficacy against a variety of B-cell malignancies. Given the prominent role of CYP3A in ibrutinib metabolism, effect of coadministration of CYP3A perpetrators with ibrutinib was evaluated in healthy adults. Ibrutinib (120 mg [Study 1, fasted], 560 mg [studies 2 (fasted), and 3 (nonfasted)]) was given alone...
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ژورنال
عنوان ژورنال: Clinical and Translational Science
سال: 2019
ISSN: 1752-8054,1752-8062
DOI: 10.1111/cts.12716