Isotretinoin-induced skeletal hyperostosis

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Isotretinoin-induced skeletal hyperostosis

We describe a case of skeletal hyperostosis in a 29 year old man presenting with non-inflammatory back pain with a past history of isotretinoin therapy for acne. The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. The prevalence and severit...

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Diffuse idiopathic skeletal hyperostosis: Forestier's disease.

Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is characterized by calcification and ossification of soft tissue entheses of ligaments and tendons. DISH is believed to be a variant of osteoarthritis (OA) without the degenerative intervertebral disc and joint degenerative qualities seen in classic OA. The likely pathoetiologic causes of DISH are presented.

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Extraspinal manifestations of diffuse idiopathic skeletal hyperostosis.

DISH is a condition characterized by calcification and/or ossification of soft tissues, mainly entheses, ligaments and joint capsules. Its prevalence increases with age and, therefore, DISH is a relatively common entity in the elderly. The classical site of involvement is the spinal column with right anterolateral soft tissue ossification being the most characteristic feature. However, DISH is ...

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Diffuse idiopathic skeletal hyperostosis. A case report.

Diffuse idiopathic skeletal hyperostosis is a disease of old age, in which there is bony proliferation of spine in ventral and lateral aspects of vertebral body. A 80-years-old male presented to us with features of low back pain radiating along the right lower limb in the posterolateral aspect. After examination and investigations, he was found to have metabolic syndrome, degenerative lumbar di...

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Isotretinoin-induced inflammatory bowel disease.

Three case reports on inflammatory bowel disease associated with use of isotretinoin are described. All three patients were male adolescents, in good health when starting isotretinoin (for acne treatment for about six months). Several weeks after discontinuation of isotretinoin the patients developed severe symptoms requiring hospitalisation. The diagnosis of ulcerative colitis was made in two ...

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ژورنال

عنوان ژورنال: SpringerPlus

سال: 2014

ISSN: 2193-1801

DOI: 10.1186/2193-1801-3-698