Isotope Bioassay for "Thrombopoietin"

Clinical indications for thrombopoietin and thrombopoietin-receptor agonists.

Thrombocytopenia is a common hematologic disorder. Stimulation of thrombopoiesis may reduce the risk for thrombocytopenia-induced bleeding, prevent severe thrombocytopenia, and reduce the need for platelet transfusion. The key cytokine is thrombopoietin (TPO). It regulates proliferation and maturation of megakaryocytes as well as platelet production. TPO is synthesized in the liver. Development...

Defining units for thrombopoietin.

Thrombopoietin.

By Shirley Ebbe I T HAS BEEN CLEAR for almost 20 years that platelet production is subject to homeostatic regulatory mechanisms that result in stimulation when the platelet count is li w’ and suppression when it is high.2 In spite of elapsed time, the physiologic processes that are involved in those regulatory mechanisms are not clear. Thrombocytopoiesis may be regulated by a humoral thrombopoi...

Calculation of the rotational bands for the 20Ne isotope

The phenomenon of clustering in light nuclei is one of the interesting topics while its study is difficult. In this article, a simple model (the two-particle model which includes a core and a cluster) is presented for the investigation of the positive and the negative parity of rotational bands of 20Ne isotope. The Deng-Fan and the Hellman potentials are considered as the core and the cluster p...

Hemagglutination - Inhibition Assay for Thrombopoietin

A sensitive immunoassay procedure for the detection of the thrombopoietic-stimulating factor (TSF) has been developed. This procedure Is similar to the hemagglutination-inhibition (HAl) technique that is available for erythropoietin. For the production of TSF, sheep were made thrombocytopenic by the Injection of antiplatelet serum. TSF from sheep sera was partially purified by column chromatogr...