Isoprenoids Control Germ Cell Migration Downstream of HMGCoA Reductase
نویسندگان
چکیده
منابع مشابه
Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation.
Hydroxymethylglutaryl coenzyme A reductase (HMGCoAR) is required for isoprenoid and cholesterol biosynthesis. In Drosophila, reduced HMGCoAR activity results in germ cell migration defects. We show that pharmacological HMGCoAR inhibition alters zebrafish development and germ cell migration. Embryos treated with atorvastatin (Lipitor) exhibited germ cell migration defects and mild morphologic ab...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2004
ISSN: 1534-5807
DOI: 10.1016/s1534-5807(04)00023-1