Isolation, Structural Elucidation, In Vitro Anti-?-Glucosidase, Anti-?-Secretase, and In Silico Studies of Bioactive Compound Isolated from Syzygium cumini L.

Diabetes is one of the main health issues worldwide because its lifetime duration. To overcome this problem, current study was conducted. This investigation aims to explore ?-glucosidase and ?-secretase potential extract/fractions pure isolated compounds Syzygium cumini bark. The chloroform extract bark subjected chromatographic analysis yield compound 1. structure phytochemical (1) conducted using advanced spectroscopic analysis. Among test extracts, fraction exhibited a significant effect against with % activity 86.20% an IC50 77.09 µM, while promising 91.54 value 17.54 ?M. 1 also showed effects enzyme, having 83.21 91.54% values 318.76 ?M, respectively. were found possess inhibitory ?-secretase. research project opens new avenue for into detailed chemical biological studies on isolate bioactive enzyme inhibitors. Furthermore, friedelin docked active site ?-glucosidase. molecular docking assessed via MOE-Dock tool. results good scores ?6.84 ?6.46 when ?-glucosidase, respectively, strong interactions.