Isolation of a Second Avian Leukosis Group-Specific Antigen (gs-b) from Avian Myeloblastosis Virus
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چکیده
منابع مشابه
Radioimmunoassay of the group-specific antigen in detection of avian leukosis virus infection.
The major group-specific antigen (gs-a) of avian leukoviruses was detected by radioimmunoassay in extracellular medium of all embryonic cultures prepared from infected chickens. Embryos of birds not carrying an avian ]eukosis virus infection and of chickens from a leukosis-free flock could thus clearly be distinguished from infected ones. Release of group-specific antigen into the extracellular...
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Ultrastructural studies of chick embryo cells morphological ly altered by strain MC29 avian leukosis virus revealed marked and characteristic differences from normal cells and cells al tered by infection with other avian tumor viruses. Such differ ences were manifest in part in the cytoplasm by high content of free ribosomes, poorly developed rough endoplasmic reticu lum, frequent fat droplets,...
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A protein kinase associated with purified virions of avian myeloblastosis BAI strain A was partially purified by ion-exchange chromatography and gel filtration. The transfer of phosphate catalyzed by this enzyme required a divalent metal ion and ATP as phosphate donor. GTP could not be substituted for ATP, and the reaction was unaffected by either cyclic AMP or beef-heart protein-kinase inhibit...
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Previous reports described the induction of avian renal neoplasms by leukosis virus strains BAI A [avian myeloblastosis virus (AMV)] and MC29, and illustrated morphological characteristics of the tumors. Continued studies in this work confirm evidence of the origin of the tumors from embryonal cells residual in the posthatched chick. The work further emphasizes differences in histopathology of ...
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2 O'Conor, G. T., A. S. Rabson, A. Malmgren, I. K. Berezesky, and F. J. Paul, J. Natl. Cancer Inst., 34, 679 (1965). 8 Rowe, W. P., and S. G. Baum, J. Exptl. Med., 122, 955 (1965); Schell, K., W. T. Lane, M. J. Casey, and R. J. Huebner, these PROCEEDINGS, 55, 81 (1966). 4 Huebner, R. J., R. M. Chanock, B. A. Rubin, and M. J. Casey, these PROCEEDINGS, 52, 1333 (1964). 6 Rowe, W. P., and S. G. Ba...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1970
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.67.2.837