Isoform‐dependent modification of T‐type calcium channels by ProTxII
نویسندگان
چکیده
منابع مشابه
Calcium signalling: Setting store by calcium channels
Recent work, stemming from genetic studies of phototransduction in Drosophila, has identified a set of homologous channel proteins that appear to mediate capacitative Ca2+ entry in species from worms and files to humans.
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There is strong evidence demonstrating that nifedipine dissolved in ethanol selectively inhibits only L-type Ca2+ current. In addition, acute ethanol exposure reduces voltage-dependent calcium currents. In the present study, we investigated the antagonistic effect of fixed concentration of nifedipine dissolved in different concentration of ethanol on L-type Ca2+ current. In a Na+-K+ free soluti...
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Homologues of Drosophila trp genes have been isolated from mammalian species in hope that they may constitute the molecular basis of capacitative Ca(2+) entry. Expression of Trps suggests that they form Ca(2+) influx channels regulated by either store depletion or a more upstream event. Store-operated Trp channels can be formed by heteromultimerization.
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Ca2+ is the most widely used second messenger in cell biology and fulfills a plethora of essential cell functions. One of the most exciting findings of the last decades was the involvement of Ca2+ in the regulation of long-term cell adaptation through its ability to control gene expression. This finding provided a link between cell excitation and gene expression. In this review, we chose to foc...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.608.14