Isoeugenitol, a cyclooxygenase-1 inhibitor from Gethyllis ciliaris
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منابع مشابه
The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor on Noise- Induced Hearing Loss
Objective(s): Noise-induced hearing loss (NIHL) is the major cause of acquired hearing loss. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is a non- steroidal anti- inflammatory drug (NSAID) with known antioxidant and antineoplastic activity. Therefore, we monitored the extent of temporary noise- induced threshold shifts (TTS) and cochlear damage caused by high level 4- kHz noise exposure t...
متن کاملFrom the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors.
The blockade of Akt activation through the inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1) represents a major signaling mechanism whereby celecoxib mediates apoptosis. Celecoxib, however, is a weak PDK-1 inhibitor (IC(50), 48 microM), requiring at least 30 microM to exhibit discernable effects on the growth of tumor cells in vitro. Here, we report the structure-based optimization of...
متن کامل[Specific cyclooxygenase-2 inhibitor analgesics: therapeutic advances.].
BACKGROUND AND OBJECTIVES Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are among the most widely prescribed drugs, including for Anesthesiology. This review aimed at discussing some current cycloxygenase biochemical aspects, which have provided the basis for the development of new analgesic and anti-inflammatory drugs. CONTENTS These drugs primarily act by inhibiting cycloxygenase (COX), whi...
متن کاملthe effect of celecoxib, a cyclooxygenase-2 inhibitor on noise- induced hearing loss
objective(s): noise-induced hearing loss (nihl) is the major cause of acquired hearing loss. celecoxib, a cyclooxygenase-2 (cox-2) inhibitor, is a non- steroidal anti- inflammatory drug (nsaid) with known antioxidant and antineoplastic activity. therefore, we monitored the extent of temporary noise- induced threshold shifts (tts) and cochlear damage caused by high level 4- khz noise exposure t...
متن کاملPreferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor.
Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, is overexpressed in many types of malignant tumors, where it mediates production of prostaglandins (PGs), which in turn may stimulate tumor growth and protect against damage by cytotoxic agents. This study investigated whether SC-'236, a selective inhibitor of COX-2, potentiates antitumor efficacy of radiation without increasing ...
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ژورنال
عنوان ژورنال: South African Journal of Botany
سال: 2007
ISSN: 0254-6299
DOI: 10.1016/j.sajb.2006.06.008