Ischemia/Reperfusion Injury in Human Kidney Transplantation
نویسندگان
چکیده
منابع مشابه
Kidney Transplantation in Iran
Kidney transplantation in patients with end stage renal disease is preferred to dialysis because transplantation provides a better quality of life andimproved survival. However, the gap between the supply and demand for a renal allograft is widening and the waiting time is increasing. Iranian protocol, a controlled transplant program supported by the government for living unrelated donors, was ...
متن کاملIschemia Reperfusion Injury in Kidney Transplantation
Ischemia and reperfusion have been a natural step during kidney transplantation. Impairment of blood flow starts with brain death due to severe hemodynamic disturbances in cadaveric donor. Clamping of renal artery causes an absolute ischemia during harvesting operation. Cold ischemia during allograft kidney storage may also cause additional ischemic damages (Southard et al. 1985; Ploeg et al.19...
متن کاملCold Ischaemic Injury in Kidney Transplantation
Kidney transplantation is considered the best treatment for end stage renal failure (ESRF) with longer life expectancy and superior quality of life compared to dialysis therapy [1-3]. However, a major constraint to transplantation is the lack of suitable organ donors. To increase the number of available organs there has been an incentive to use ‘marginal’ donors such as donation after cardiac d...
متن کاملIschaemia Reperfusion Injury in Kidney Transplantation
The disruption of an organ’s blood supply is obligatory in clinical transplantation occurring at the time of organ procurement. During this ischaemic period complex pathophysiological changes occur within the organ that leave it primed in a pro-inflammatory state. Although the re-establishment of blood flow is essential to halt ongoing ischaemic damage, the organ incurs additional injury. This ...
متن کاملIschemia-reperfusion injury in kidney transplantation.
Ischemia-reperfusion injury to the kidney is a complex pathophysiological process that has importance during transplantation as it affects graft function and survival. It starts with the physiological changes associated with the death of the donor, including the direct effects of hypoxia and metabolic stress. The injury continues through the organ procurement and preservation procedures. Upon r...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 1998
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65598-8