Is This a Clinical Trial? And Should It Be Registered?

[Is this clinical trial fully registered?].

In September 2004, the members of the International Committee of Medical Journal Editors (ICMJE) published a joint editorial aimed at promoting registration of all clinical trials [1]. We stated that we will consider a trial for publication only if it has been registered before the enrollment of the first patient. This policy applies to trials that start recruiting on or after July 1, 2005. Bec...

Should all clinical trials of oral health be registered?

Randomised controlled trials (RCTs) and their metaanalyses are considered the gold standard to making informed decisions about which treatment is best. In fact, meta-analyses combine the findings of several RCTs and may overcome the limitations of individual trials. However, because of the vast amount of unpublished results of RCTs, the conclusions of a systematic review can be misleading1. Was...

Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors.

Artificial Intelligence: What It Is, and What It Should Be

What Artificial Intelligence (AI) is at the current time is not what it should be. The mainstream works in the field are on domain-specific problems and solutions. Instead, AI should focus on general-purpose systems that are adaptive to its environment, and can work with insufficient knowledge and resources. AI in this sense is unified with Cognitive Science at a general level, with the latter ...

Tigecycline: what is it, and where should it be used?

Tigecycline is the first glycylcycline to be launched and is one of the very few new antimicrobials with activity against Gram-negative bacteria. It evades acquired efflux and target-mediated resistance to classical tetracyclines, but not chromosomal efflux in Proteeae and Pseudomonas. Cmax+ is low, but tissue penetration is excellent and the compound has shown equivalence to imipenem/cilastati...