منابع مشابه
Somatic Mutation and Autoimmunity
Upon reading Christopher Goodnow’s recent Review article in Cell, which emphasized the overlapping role of somatic mutation in autoimmunity and cancer (Goodnow, 2007), I was reminded of a graduate lecture course given by Professor Roderick MacLeod in 1995 at the University of Illinois. While introducing F.M. Burnet’s clonal selection theory to our small class, Professor MacLeod mentioned Burnet...
متن کاملComparing somatic mutation-callers
Background: Somatic mutation-calling based on DNA from matched tumor-normal patient samples is one of the key tasks carried by many cancer genome projects. One such large-scale project is The Cancer Genome Atlas (TCGA), which is now routinely compiling catalogs of somatic mutations from hundreds of paired tumor-normal DNA exome-sequence data. Nonetheless, mutation calling is still very challeng...
متن کاملThe Concept of Somatization: What Is and What Is Not Somatizing. A) Perception of Somatic Symp-
Daily physiological processes, excessive physical fatigue, sub-clinical viral infections and certain environmental situations can all cause some kind of physical pain or distress in 75% of adults in a typical week. When the individual refuses to accept medical opinion and attributes the pain to a physical illness and persistently seeks diagnosis and treatment, then there is a possibility of an ...
متن کاملSomatic mutation in the neonatal mouse.
Several mechanisms that diversify the adult immune repertoire, such as terminal deoxynucleotidyl transferase-dependent N region addition, are not available to the neonatal mouse. One important process that contributes to protective immunity in the adult is somatic mutation, which plays a major role in the generation of high affinity memory B cells. It is not clear whether B cells in the neonata...
متن کاملSomatic mutation and the Antarctic ozone hole
1 Previous studies of Antarctic clonal moss populations using RAPD markers have reported extraordinarily high levels of genetic variation. This has been claimed to reflect somatic mutation, possibly resulting from elevated UV-B radiation. 2 Our study used microsatellite markers to compare the genetic variation present within continental Antarctic, sub-Antarctic and temperate populations of the ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1968
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780110113