Is sodium cromoglycate effective in nocturnal asthma?
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Is sodium cromoglycate effective in nocturnal asthma?
Nocturnal asthma is potentially dangerous' 2 and may be difficult to treat. Slow release oral preparations of methylxanthines3 or high dose aerosol treatment with /2 stimulants4 have been advocated. In our experience, however, both of these groups of drugs may be quite ineffective in some patients and many patients cannot tolerate methylxanthines in effective doses. The dose of sympathomimetic ...
متن کاملSodium cromoglycate in nocturnal asthma.
To investigate whether mast cell degranulation was important in producing nocturnal asthma, the effect of a single high dose of nebulised sodium cromoglycate on overnight bronchoconstriction, oxygen saturation, and breathing patterns in eight patients with nocturnal wheeze was examined. The study took the form of a double blind placebo controlled crossover comparison. Treatment with cromoglycat...
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The review of placebo controlled trials of sodium cromoglycate (SCG) in childhood asthma by Tasche et al concludes that “there is insuYcient evidence that SCG has a beneficial eVect as maintenance treatment in children with asthma”. We do not believe this conclusion is justified. The principal criteria for assessing the eYcacy of inhaled SCG are the mean diVerences in the eVect on the symptoms ...
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In the past decade, the Lreaune nt of usLhma has changed. This evolution occurred with the realization that prevention of regular asthma symptoms is preferable to treatme nt of asthmatic symptoms when they develop. Thi s unders tanding is reflected in the consensus reports on asthma management , which have rece ntly been publi shed in several countries ll-41 . These reports agree that the main ...
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In thirteen patients with extrinsic asthma the effects of placebo, sodium cromoglycate, ipratropium bromide, and ipratropium bromide plus sodium cromoglycate were studied in a random double-blind fashion to assess their inhibitory action in exercise-induced asthma (EIA). Exercise testing consisted of steady state running on an inclined treadmill for up to eight minutes. In eight of the 13 patie...
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ژورنال
عنوان ژورنال: Thorax
سال: 1985
ISSN: 0040-6376
DOI: 10.1136/thx.40.10.793