Is In Vitro Antibiotic Combination More Effective than Single-Drug Therapy against Anthrax?

Is in vitro antibiotic combination more effective than single-drug therapy against anthrax?

Antibiotic combinations are used to enhance antibacterial efficacy and to prevent the development of resistance. We have tested a possible synergistic effect of several antibacterial combinations on Bacillus anthracis. The in vitro activities of antibiotic combinations against two strains of B. anthracis, strain Sterne and the Russian anthrax vaccine strain STi, were tested by the fractional in...

Combination Therapy with Antibiotics and Anthrax Immune Globulin Intravenous (AIGIV) Is Potentially More Effective than Antibiotics Alone in Rabbit Model of Inhalational Anthrax

BACKGROUND We have evaluated the therapeutic efficacy of AIGIV when given in combination with levofloxacin and the effective window of treatment to assess the added benefit provided by AIGIV over standard antibiotic treatment alone in a New Zealand white rabbit model of inhalational anthrax. METHODS Rabbits were exposed to lethal dose of aerosolized spores of Bacillus anthracis (Ames strain) ...

ipratropium bromide is more effective than salmeterol fluticason combination on o2 saturation patients with copd

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Is cognitive–behavioral therapy more effective than other therapies?

Combo Infliximab, Azathioprine More Effective Than Either Drug Alone in CD Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

Background: Therapy of Crohn disease (CD) with anti-tumor necrosis factor biologics and/or immunomodulators has altered the disease natural history. The comparative efficacy and safety of these medications alone or in combination is unknown. Objective: To evaluate the efficacy and safety of infliximab (IFX) monotherapy, azathioprine (AZA) monotherapy, and combination therapy in patients with mo...