Is clonidine an anaesthetic in man?

The Antihypertensive Mechanism of Clonidine in Man

Recordings of multi-unit sympathetic activity were made from muscle branches of the peroneal nerve during i.v. bolus injection of 100 to 275 pg clonidine in seven hypertensive patients. Blood pressure was reduced in all patients, but sympathetic activity and heart rate could either increase or decrease. When plasma levels of clonidine were low, sympathetic activity tended to Increase, and when ...

Interaction between clonidine and desipramine in man.

Interaction between the tricyclic antidepressant desipramine and the antihypertensive agent clonidine has been investigated in five hypertensive patients in a double-blind placebo controlled study. Introduction of the tricyclic antidepressant led to loss of blood pressure control in four of the patients. The average blood pressure rise in the desipramine period compared with the placebo period ...

Perioperative immunity: is there an anaesthetic hangover?

receptor blocker withdrawal. A preoperative problem in general surgery? Acta Anaesthesiol Scand Suppl 1982; 76: 32–7 26 Crandell DL. The anesthetic hazards in patients on antihypertensive therapy. J Am Med Assoc 1962; 179: 495–500 27 Viljoen JF, Estafanous FG, Kellner GA. Propranolol and cardiac surgery. J Thorac Cardiovasc Surg 1972; 64: 826–30 28 Ellenberger C, Tait G, Beattie WS. Chronic bet...

Comparison of seven intravenous anaesthetic agents in man.

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No man is an island.